PHYSICOCHEMICAL STABILITY OF HYDROXYAPATITE– LOW-MOLECULAR POLYETHYLENE GLYCOL 400 COMPOSITE SYSTEMS IN BIOLOGICAL MEDIA

Abstract

The physicochemical stability of the composite system consisting of hydroxyapatite (HAP) with 10, 25, and 50% polyethylene glycol (PEG) with a molecular weight of 400 in physiological solutions of different chemical composition has been studied. In the interaction HAP + PEG 400 composite system with physiological solutions, the amount of Ca in the filtrate changes depending on the PEG content of the composite and salt composition of the reaction media. The rate of calcium release in Ringer and Ringer–Lokk solutions, whose chemical composition is close to that of the tissue fluid of living organisms, is almost twice as high as in a 0.9% NaCl solution. Chemical analysis methods have shown that the HAP + PEG 400 composite system interacts with physiological solutions and is likely to promote the calcium interchange between the experimental material and tissue fluid. Infrared spectroscopy has demonstrated that polyethylene glycol is present in the HAP + 10% PEG system over 120 h of interaction with biological media of living organisms, which will promote the recovery of nervous impulses in the treatment of bone defects. The HAP + PEG 400 composite system can be recommended for further studies in the development of novel composite materials in the area of rehabilitation orthopedics.